Lucentis

Lucentis is a type of anti-VEGF drug called a monoclonal antibody fragment that was developed to treat retinal diseases. It is injected directly into the eye, and can stabilize or even improve vision loss. According to the Lucentis package label, best results occur when 0.5 mg of Lucentis is given every month. Some Retinal Specialists give Lucentis less frequently than every month.

 

Data from clinical trials involving more than 1,300 people have shown that after two years of treatment, monthly injections of 0.5 mg of Lucentis stabilizes vision for an estimated 90% of patients (their vision did not get significantly worse). Vision improved significantly for approximately 30% of treated patients.

 

Commonly reported side effects of Lucentis injections include conjunctival hemorrhage, eye pain, floaters, increased eye pressure, and inflammation of the eye. Serious complications of injections in the eye include endophthalmitis (infection) and retinal detachment.

 

References Rosenfeld PJ, Brown DM, Heier JS, et al. Ranibizumab for neovascular age-related macular degeneration. N Engl J Med 2006;355:1419-31.

Brown DM, Kaiser PK, Michels M, et al. Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N Engl J Med 2006;355:1432-44.